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Pancreatic Islet Cell Transplantation
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Reasons for Procedure
- Toxicity from immunosuppressive agents
- Injury to the liver or the pancreas
- Cholesterol problems
- Sensitization—Formation of islet cell antibodies that increase the chance of rejection for this or any future transplant. This may occur from a previous transplants, a blood transfusion, or pregnancy.
- Return of diabetes symptoms that need to be treated with resumption or increased use of self-injected insulin
- Nausea, vomiting, and abdominal pain
- Blood clots
- Worsening of kidney function
- Worsening of high blood pressure
What to Expect
Prior to Procedure
Description of Procedure
Immediately After Procedure
How Long Will It Take?
How Much Will It Hurt?
Average Hospital Stay
- Follow your doctor's instructions on how to check your blood glucose on a frequent basis.
- You and your doctor will closely control and monitor blood sugar levels with the a new insulin requirement. The dose of insulin will need to be adjusted after the transplant.
- Washing their hands
- Wearing gloves or masks
- Keeping your incisions covered
- Washing your hands often and reminding visitors and healthcare providers to do the same
- Reminding your healthcare providers to wear gloves or masks
- Not allowing others to touch your incision
Call Your Doctor
- Signs of infection, including fever and chills
- Redness, swelling, increasing pain, excessive bleeding, or discharge from the incision site
- Cough, shortness of breath, chest pain, or severe nausea or vomiting
- High or low blood glucose levels
American College of Surgeons http://www.facs.org
American Diabetes Association http://www.diabetes.org
Canadian Diabetes Association http://www.diabetes.ca
Canadian Digestive Health Foundation http://www.cdhf.ca
Bertuzzi F, Marzorati S, et al. Islet cell transplantation. Curr Mol Med. 2006;6:369-74.
Campbell, PM, Senior, PA, et al. High risk of sensitization after failed islet transplantation. Am J Transplant. 2007; 7:2311.
Demartines N, Schiesser M, et al. An evidence-based analysis of simultaneous pancreas-kidney and pancreas transplantation alone. Am J Transplant. 2005;5:2688-97.
Diabetes mellitus type 1. EBSCO DynaMed website. Available at: http://dynamed.ebscohost.com/dynamed. Updated August 9, 2013. Accessed September 3, 2013.
Fiorina P, Secchi A. Pancreatic islet cell transplant for treatment of diabetes. Endocrinol Metab Clin N Am. 2007;36:999-1013.
Hogan A, Pileggi a, Ricordi C. Transplantation: current developments and future directions: the future of clinical islet transplantation as a cure for diabetes. Front Biosci. 2008;13: 1192-205.
Islet transplantation. American Diabetes Association website. Available at: http://www.diabetes.org/living-with-diabetes/treatment-and-care/transplantation/islet-transplantation.html. Accessed September 3, 2013.
Leitao CB, Cure P, et al. Current challenges in islet transplantation. Curr Diab Rep. 2008;8:324-31.
Roberson RP. Islet transplantation as a treatment for diabetes: a work in progress. N Engl J Med . 2004;350:694-705.
Shapiro AM, Ricordi C, et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med. 2006; 355:1318.
6/3/2011 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance http://dynamed.ebscohost.com/dynamed: Mills E, Eyawo O, et al. Smoking cessation reduces postoperative complications: a systematic review and meta-analysis. Am J Med. 2011;124(2):144-154.e8.
- Reviewer: Michael Woods, MD
- Review Date: 09/2013
- Update Date: 00/12/2014