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What Is Pokeroot Used for Today?
1 Stolberg M. The miraculous effects of taking laxatives. Success and failure of pre-modern medical treatment from the patients' perspective. Wurzbg Medizinhist Mitt . 2003;22:167–77.
2 Picard D, Kao CC, Hudak KA, et al. Pokeweed antiviral protein inhibits brome mosaic virus replication in plant cells. J Biol Chem . 2005;280:20069–75.
3 Uckun FM, Rustamova L, Vassilev AO, et al. CNS activity of pokeweed anti-viral protein (PAP) in mice infected with lymphocytic choriomeningitis virus (LCMV). BMC Infect Dis . 2005;5:9.
4 Parikh BA, Baykal U, Di R, et al. Evidence for retro-translocation of pokeweed antiviral protein from endoplasmic reticulum into cytosol and separation of its activity on ribosomes from its activity on capped RNA. Biochemistry . 2005;44:2478–90.
5 D'Cruz OJ, Waurzyniak B, Uckun FM, et al. Mucosal toxicity studies of a gel formulation of native pokeweed antiviral protein. Toxicol Pathol . 2004;32:212–21.
6 D'Cruz OJ, Waurzyniakt B, Uckun FM, et al. A 13-week subchronic intravaginal toxicity study of pokeweed antiviral protein in mice. Phytomedicine . 2004;11:342–51.
7 Parikh BA, Tumer NE. Antiviral activity of ribosome inactivating proteins in medicine. Mini Rev Med Chem . 2004;4:523–43.
8 Hudak KA, Bauman JD, Tumer NE, et al. Pokeweed antiviral protein binds to the cap structure of eukaryotic mRNA and depurinates the mRNA downstream of the cap. RNA . 2002;8:1148–59.
9 Parikh BA, Coetzer C, Tumer NE, et al. Pokeweed antiviral protein regulates the stability of its own mRNA by a mechanism that requires depurination but can be separated from depurination of the alpha-sarcin/ricin loop of rRNA. J Biol Chem . 2002;277:41428–37.
10 Turpin JA. Considerations and development of topical microbicides to inhibit the sexual transmission of HIV. Expert Opin Investig Drugs . 2002;11:1077–97.
11 Yamaguchi K, Uechi M, Katakura Y, et al. Mitogenic properties of pokeweed lectin-D isoforms on human peripheral blood lymphocytes: non-mitogen PL-D1 and mitogen PL-D2. Biosci Biotechnol Biochem . 2004;68:1591–3.
12 Yan S, Marguet D, Dobers J, et al. Deficiency of CD26 results in a change of cytokine and immunoglobulin secretion after stimulation by pokeweed mitogen. Eur J Immunol . 2003;33:1519–27.
13 Barabas E, Kemeny B, Gonzalez R, et al. A comparison of the lymphoproliferative capacity of pokeweed mitogen (PWM) and phytohaemagglutinin (PHA) in CCR-5 wild-type and heterozygous HIV-infected and uninfected subjects. Int J STD AIDS . 2002;13:691–7.
14 Wang S, Panter KE, Evans RC, et al. The effects of pokeweed mitogen (PWM) and phytohemagglutinin (PHA) on bovine oocyte maturation and embryo development in vitro. Anim Reprod Sci . 2001;67:215–20.
15 Wimer BM, Mann PL. Mitogen immunotherapy for HIV infections exemplified by phytohemagglutinin and pokeweed mitogen. Cancer Biother Radiopharm . 2001;15:629–44.
16 Wimer BM, Mann PL. Apparent pokeweed mitogen cure of metastatic gum melanoma in an older dog. Cancer Biother Radiopharm . 2000;15:201–5.
17 Sjoberg O, Kurnick J. Conditions for induction of specific and polyclonal antibody production by Cowan 1 bacteria and by pokeweed mitogen. Scand J Immunol . 1998;11:47–51.
18 Lazarus DD, Trimble LA, Moldawer LL, et al. The metabolic effects of pokeweed mitogen in mice. Metabolism . 1998;47:75–82.
19 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals . London: The Pharmaceutical Press. 1996:215–217.
20 Roberge R, Brader E, Martin ML, et al. The root of evil—pokeweed intoxication. Ann Emerg Med . 1986;15:470–3.
21 Barker BE et al. Haematological effects of pokeweed. Lancet 1967;1:437.
22 Barker BE et al. Peripheral blood plasmacytosis following systemic exposure to Phytolacca americana (pokeweed). Pediatrics . 1966;38:490–493.
23 Barker BE et al. Mitogenic activity in Phytolacca americana (pokeweed). Lancet . 1965;1:170.
24 Yamaguchi K, Uechi M, Katakura Y, et al. Mitogenic properties of pokeweed lectin-D isoforms on human peripheral blood lymphocytes: non-mitogen PL-D1 and mitogen PL-D2. Biosci Biotechnol Biochem . 2004;68:1591–3.
- Reviewer: EBSCO CAM Review Board
- Review Date: 09/2014
- Update Date: 09/18/2014