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Japanese Encephalitis Vaccine
What Is Japanese Encephalitis?
- Neck stiffness
- Brain damage
- Convulsions, especially in infants
What Is the Japanese Encephalitis Vaccine?
Who Should Get Vaccinated and When?
- Planning to stay at least a month where there have been Japanese encephalitis
- Planning on staying less than a month, but will be in rural areas or outdoors a lot
- Going to an area of Japanese encephalitis outbreaks
- Unsure where they will be staying
What Are the Risks Associated With the Japanese Encephalitis Vaccine?
- Soreness, redness, or swelling near the injection site
- Muscle pain
Who Should Not Get Vaccinated?
- Have ever had a life-threatening reaction to this vaccine
- Have severe allergic reactions
- Are pregnant
- Will be traveling to an urban area for less than 30 days
What Other Ways Can Japanese Encephalitis Be Prevented Besides Vaccination?
- Staying in well-screened areas
- Wearing clothes that cover most of the body
- Using an effective insect repellent (such as those containing up to 30% N,N-diethyl-meta-toluamide, [DEET]) on skin and clothing to prevent mosquito bites
What Happens in the Event of an Outbreak?
WHERE CAN I GET MORE INFORMATION?
Centers for Disease Control and Prevention http://www.cdc.gov
Immunization Action Coalition http://www.immunize.org
Clinical trials sites in the United States for Ixiaro in children under 17. Centers for Disease Control and Prevention website. Available at http://www.cdc.gov/ncidod/dvbid/jencephalitis/resources/UpdtJEVaccChildren%5FWeb%5FTable1.pdf. Accessed November 19, 2013.
Dubischar-Kastner K, Kaltenboeck A, et al. Safety analysis of a Vero cell culture-derived Japanese encephalitis vaccine, IXIARO (IC51), in 6 months of follow-up. Vaccine. 2010;28(39):6463-6469.
Fischer M, Lindsey N, et al; Centers for Disease Control and Prevention (CDC). Japanese encephalitis vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2010;59(RR-1):1-27.
Halstead SB, Thomas SJ. New Japanese encephalitis vaccines: alternatives to production in mouse brain. Expert Rev Vaccines. 2011;10(3):355-364.
Halstead SB, Thomas SJ. Japanese encephalitis: new options for active immunization. Clin Infect Dis. 2010;50(8):1155-1164.
Japanese encephalitis. EBSCO DynaMed website. Available at: https://dynamed.ebscohost.com/about/about-us. Updated May 22, 2013. Accessed November 19, 2013.
Japanese encephalitis vaccine: What you need to know. Centers for Disease Control and Prevention website. Available at: http://www.immunize.org/vis/je%5Fixiaro.pdf. Updated December 7, 2011. Accessed November 19, 2013.
Lehtinen VA, Huhtamo E, Siikamäki H, Vapalahti O. Japanese encephalitis in a Finnish traveler on a two-week holiday in Thailand. J Clin Virol. 2008;43(1):93-95.
Wilder-Smith A, Halstead SB. Japanese encephalitis: update on vaccines and vaccine recommendations. Curr Opin Infect Dis. 2010;23(5):426-431.
- Reviewer: David Horn, MD
- Review Date: 11/2013
- Update Date: 11/19/2013