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Risk Factors for Bipolar Disorder
- Genetic factors— Bipolar disorder can run in families. There is a high likelihood that there is a genetic component to this disorder. Eighty to ninety percent of individuals with bipolar disorder have a relative with either depression or bipolar disorder. Bipolar disorder is not caused by one specific gene. It is caused by many genes that act together.
- Medicines and conditions—Some medicines (such as corticosteroids, cancer medicines), several medical conditions (such as thyroid disease, vitamin deficiencies, end-stage renal disease), and certain neurological diseases (such as Parkinson's syndrome , dementia) may present with features of bipolar disorder. The diagnosis of bipolar disorder is made only when none of these conditions are present.
Bipolar disorder. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed . Updated September 17, 2012. October 12, 2012.
Bipolar disorder. National Institute of Mental Health website. Available at: http://www.nimh.nih.gov/health/publications/bipolar-disorder/complete-index.shtml . Updated 2008. Accessed October 12, 2012.
Carson RC, Butcher JN. Abnormal Psychology and Modern Life . 11th ed. New York, NY: Allyn and Bacon; 2000.
Estevez RF, Suppes T. Maintenance treatment in bipolar I disorder. In: Yatham LN, Kusumakar V, eds. Bipolar Disorder: A Clinician’s Guide to Biological Treatments . New York, NY: Taylor & Francis Group, LLC.; 2009: 107-152.
Fusar-Poli P, et al. Mapping vulnerability to bipolar disorder: a systematic review and meta-analysis of neuroimaging studies. J Psychiatry Neurosci . 2012;37:170-84.
Salvadore G, Drevets WC, Henter ID, Zarate CA, Manji HK. Early intervention in Bipolar Disorder, Part II: Therapeutics. Early Interv Psychiatry . 2008;2(3):136-146.
- Reviewer: Rimas Lukas, MD
- Review Date: 09/2013
- Update Date: 09/30/2013