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Hydralazine

Trade Names :

  • Apresoline
Vitamin B6 - Supplementation Likely Helpful Coenzyme Q10 (CoQ10) - Supplementation Possibly Helpful Coleus forskohlii - Theoretical Interaction
Hydralazine causes dilation of the walls of blood vessels and is sometimes used to treat hypertension.
 
Vitamin B6
Hydralazine is known to deplete the blood of vitamin B 6 . Taking B 6 supplements may prevent or reverse side effects of the medication. 1,2
Coenzyme Q10 (CoQ10)
There is some evidence that hydralazine might impair the body's ability to manufacture the substance coenzyme Q 10 (CoQ 10 ). 3 This suggests (but definitely does not prove) that taking CoQ 10 supplements may produce a beneficial effect.
Coleus forskohlii
The herb Coleus forskohlii relaxes blood vessels and might have unpredictable effects if combined with hydralazine.

References

1
Shils M, et al. (eds.). Modern nutrition in health and disease, 9th ed. Baltimore: Williams and Wilkins, 1999: 1634.
2
Goodman L and Gilman A. The pharmacological basis of therapeutics, 9th ed. Hardman J, et al (eds.). New York: McGraw-Hill, 1996: 1562.
3
Kishi H, et al. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q 10 -enzymes by clinically used anti-hypertensive drugs. Res Commun ChemPathol Pharmacol 12(3): 533–40, 1975.

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