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Persistent Pulmonary Hypertension of the Newborn
(PPHN; Persistent Fetal Circulation [PFC]; Syndrome of Pulmonary Hypertension of Newborn [SPHN])
|Circulatory System of Infant|
|Copyright © Nucleus Medical Media, Inc.|
An event or illness during pregnancy or childbirth, such as:
- Meconium aspiration syndrome (the baby inhales meconium—the first stool—prior to or shortly after birth)
- Severe pneumonia
- Low blood sugar
- Birth asphyxia (loss of oxygen to the fetus during delivery)
- Respiratory distress syndrome—caused by lungs that have not fully developed
- Use of nonsteroidal anti-inflammatory drugs (NSAIDs) by the mother during pregnancy
- Late trimester maternal use of antidepressants, especially SSRIs
- Amniotic fluid leak
- Low amniotic fluid—oligohydramnios
- Abnormal lung development as a result of congenital diaphragmatic hernia or Potter syndrome
- Stress during pregnancy
- Isolated condition with an unknown cause
- Stress to the fetus during pregnancy or delivery
- Health conditions of the mother, including diabetes
- Complications during birth or pregnancy
- Rapid breathing—tachypnea
- Rapid heart rate—tachycardia
- Difficulty breathing—signs may include flared nostrils or grunting
- Blue tint to the skin, even when the baby is receiving oxygen
Extracorporeal Membrane Oxygenation (ECMO)
- Get good prenatal care. Start as early as possible in pregnancy.
- Eat a healthful diet and take recommended vitamins.
- Avoid smoking, drinking alcohol, and taking drugs.
- Only take medications that your doctor has approved.
- Avoid taking NSAIDs or SSRIs. Talk to your doctor about alternatives that may be safer.
Healthy Children—American Academy of Pediatrics http://www.healthychildren.org
Nemours Kids Health http://www.kidshealth.org
Canadian Paediatric Society http://www.cps.ca
Health Canada http://www.hc-sc.gc.ca
Extracorporeal membrane oxygenation. Cincinnati Children's Hospital website. Available at: http://www.cincinnatichildrens.org/health/e/ecmo. Updated October 2013. Accessed September 4, 2014.
Kleigman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th ed. Saunders: Philadelphia, PA; 2007.
Lungs and respiratory system. Children's Hospital Colorado website. Available at: http://www.childrenscolorado.org/wellness-safety/health-library/for-parents/body-basics/lungs-and-respiratory-system. Accessed September 4, 2014.
Persistent pulmonary hypertension of newborn. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated January 30, 2014. Accessed September 4, 2014.
PS Shah, A Ohlsson. Sildenafil for pulmonary hypertension in neonates. Cochrane Database Syst Rev 2007; 3:CD005494.
- Reviewer: Kari Kassir, MD
- Review Date: 08/2014
- Update Date: 09/30/2013