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(PHP; Underactive Pituitary Gland)
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Compression of the Tumor
- Blurred vision
- Loss of visual field
- Poor temperature control
Insufficient levels of gonadotropins
- In premenopausal women: missed menstrual cycles, infertility , osteoporosis , vaginal dryness, loss or reduction in female characteristics
- In men: impotence , reduced size of testes, decreased production of sperm, infertility , breast enlargement, reduced muscle mass, loss or reduction in male characteristics (eg, beard growth)
Insufficient levels of growth hormone
- In children: stunted growth or dwarfism
- In adults: weakness, obesity , reduced cardiac output, low blood sugar levels, and reduced exercise tolerance
- Insufficient levels of thyroid-stimulating hormones can lead to:
Insufficient corticotrophic levels
can lead to:
- Underactive adrenal gland, which causes low blood pressure, low blood sugar , fatigue, weight loss, vomiting, and low stress tolerance—This can be life-threatening.
Excessive prolactin levels
- In women: missed periods, infertility, and milk secretion
- In men: reduced facial and body hair, small testes
- Insufficient antidiuretic hormone (rare) can cause:
- Excessive thirst and frequent urination
- Night-time urination
- MRI scan —a test that uses magnetic waves to make pictures of structures inside the body
- Blood tests—Blood tests—to measure pituitary, as well as target gland hormone levels
- Stimulation tests—to test the maximum capacity of the endocrine glands, usually of the pituitary gland
- Semen analysis—in males suspected of infertility
- Hormone replacement therapy—based on what types of hormones are missing
- Tumor removal—done if the cause of the damage is a tumor
- Radiation therapy —done if the cause of the damage is a cancer or tumor
The Hormone Foundation http://www.hormone.org/
The Pituitary Network http://www.pituitary.org/
About Kids Health http://www.aboutkidshealth.ca/
Health Canada http://www.hc-sc.gc.ca/
Bhasin S, Cunningham GR, Hayes FJ, et al. Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2006;91:1995-2010.
Diabetes & other endocrine and metabolic disorders: hypopituitarism. Lucile Packard Children's Hospital website. Available at: http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/diabetes/hypop.html . Accessed May 30, 2007.
Geffner M. Panhypopituitarism. The Magic Foundation website. Available at: http://220.127.116.11/search?q=cache:MHUYAhcYci8J:https://www.magicfoundation.org/downloads/PanPitpdf669.pdf+Panhypopituitarism&hl=en&ct=clnk&cd=8&gl=us . Accessed May 30, 2007.
Randeva HS, Schoebel J, Byrne J, et al. Classical pituitary apoplexy: clinical features, management and outcome. Clin Endocrinol (Oxf) . 1999;51:181-188.
Schneider HJ, Aimaretti G, Kreitschmann-Andermahr I, et al. Hypopituitarism. Lancet. 2007;269:1461-1470.
Toogood AA, Stewart PM. Hypopituitarism: clinical features, diagnosis, and management. Endocrinol Metab Clin North Am. 1998;37:235-261
What is a growth disorder? Nemours Foundation website. Available at: http://kidshealth.org/parent/medical/endocrine/growth%5Fdisorder.html . Accessed May 30, 2007.
- Reviewer: Kim Carmichael, MD
- Review Date: 03/2013
- Update Date: 03/01/2013