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Sex Rx: Celexa and Your Sex Life
How Citalopram Works
Other Drugs of This Class (SSRIs):
Possible Sexual Side Effects Associated with Citalopram
- Decreased sexual desire
- Difficulty with sexual arousal
- Difficulty reaching orgasm or inability to reach orgasm
- Erection impairment in men
- Delayed ejaculation
How This Medication Can Affect Sexual Function
Wait It Out
Decrease the Dosage
- Bupropion (Wellbutrin)—This antidepressant medicine does not affect serotonin. It is less likely than the commonly used SSRIs to cause sexual dysfunction and may actually have prosexual effects. Bupropion is used to treat major depressive disorder, and seasonal affective disorder. It is not recommended for people with eating disorders or seizure disorders.
- Nefazodone—This drug does affect serotonin, but not in the same way as SSRIs. It can be used to treat depression and cause fewer sexual side effects. One of its more troublesome adverse effects is sedation.
- Mirtazapine (Remeron)—This drug is similar to nefazodone in its effect on depression and sexual function. It can also cause sedation.
Try an Antidote
Take a Drug Holiday
Food and Drug Administration http://www.fda.gov/
Mental Health America http://www.nmha.org/
Canadian Psychiatric Association http://www.cpa-apc.org/
Sex Information and Education Council of Canada http://www.sieccan.org/
Amantadine. EBSCO DynaMed website. Available at: http://www.ebscohost.com/pointofcare. Updated December 22, 2010. Accessed July 14, 2012.
Antidepressant medication overview. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated March 28, 2012. Accessed July 19, 2012.
Balon R. SSRI-associated sexual dysfunction. Am J Psychiatry. 2006;163:1504-1509.
Bupropion. EBSCO Health Library website. Available at: http://www.ebscohost.com/pointofcare. Updated March 28, 2011. Accessed July 14, 2012.
Citalopram. EBSCO Health Library website. Available at: http://www.ebscohost.com/healthLibrary/. Updated March 28, 2012. Accessed July 14, 2012.
DeBattista C, Solvason B, Poirier J, et al. A placebo-controlled, randomized, double-blind study of adjunctive bupropion sustained release in the treatment of SSRI-induced sexual dysfunction. J Clin Psychiatry. 2005;66:844-8.
Modell JG, Katholi CR, Modell JD, DePalma RL. Comparative sexual side effects of bupropion, fluoxetine, paroxetine, and sertraline. Clin Pharmacol Ther. 1997;61:476-487.
Nefazodone. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php. Updated April 11, 2011. Accessed July 7, 2012.
Safarinejad MR. The effects of the adjunctive bupropion on male sexual dysfunction induced by a selective serotonin reuptake inhibitor: a double-blind placebo-controlled and randomized study. BJU Int. 2010;106(6):840-847.
Shen WW, Hsu JH. Female sexual side effects associated with selective serotonin reuptake inhibitors: a descriptive clinical study of 33 patients. Int J Psychiatry Med. 1995;25:239-248.
Sildenafil. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated April 11, 2011. Accessed July 14, 2012.
Smucny J, Park MS. Which antidepressant is best to avoid sexual dysfunction? Am Fam Physician. 2004;69(10):2419-2420.
Yohimbe. EBSCO Natural and Alternative Treatments website. Available at: http://www.ebscohost.com/healthLibrary/. Updated August 2011. Accessed July 14, 2012.
- Reviewer: Brian Randall, MD
- Review Date: 07/2012
- Update Date: 09/17/2012