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Multiple System Atrophy
(MSA; Sporadic Olivopontocerebellar Atrophy; Shy-Drager Syndrome; Parkinson’s Plus Syndrome; Multi-system Degeneration; Multi-system Atrophy; Idiopathic Autonomic Failure; Idiopathic Orthostatic Hypotension;)
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- Type MSA-A is associated with orthostatic hypotension. This is a problem managing blood pressure when moving from sitting to standing. It can lead to dizziness or fainting.
Type MSA-P is associated with symptoms similar to initial Parkisnon symptoms such as:
- Slow, stiff movements
- Clumsiness (loss of balance and coordination)
Type MSA-C is associated with:
- Difficulty swallowing
- Problems speaking and hoarseness
- Difficulty coordinating muscle movement
- Problems with bladder control
- Erectile dysfunction
- Muscle tightening around a joint that prevents free movement
- Problems with posture such as leaning to one side and forward head bend
- Inappropriate laughing or crying
- Excess yawning
- Vision problems
- Changes in writing
- MRI scan —to look for abnormalities in the brain
- Blood tests
- Lumbar puncture —to evaluate spinal fluid
- Relieve muscle rigidity
- Stabilize mood
- Manage orthostatic hypotension
- Relieve other symptoms such as constipation, urinary control problems, or erectile dysfunction
- Physical therapy—to help keep muscles strong and maintain range of motion.
- Occupational therapy—to improve ability to do daily tasks such as eating, grooming, and dressing.
- Speech therapy—to help with speaking and swallowing.
- Respiratory therapy— Continuous positive airway pressure (CPAP) for sleep apnea and other breathing problems during sleep
National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov/
National Dysautonomia Research Foundation http://www.ndrf.org/
Shy-Drager/Multiple System Atrophy Support Group http://www.shy-drager.org/
Worldwide Education and Awareness for Movement Disorders http://www.wemove.org/
Canadian Institutes of Health Research http://www.cihr-irsc.gc.ca/
Canadian Neurological Sciences Federation http://www.ccns.org/
Multiple System Atrophy. National Institute of Neurological Disorders and Stroke website. Available at: http://www.ninds.nih.gov/disorders/msa/detail%5Fmsa.htm. Accessed April 19, 2013.
Multiple System Atrophy with Orthostatic Hypotension. National Institute of Neurological Disorders and Stroke website. Available at: http://www.ninds.nih.gov/disorders/msa%5Forthostatic%5Fhypotension/msa%5Forthostatic%5Fhypotension.htm. Accessed April 19, 2013.
Multiple System Atrophy/Shy-Drager Syndrome. Vanderbilt University Medical Center website. Available at: http://www.mc.vanderbilt.edu/root/vumc.php?site=adc&doc=4791. Accessed April 19, 2013.
Multiple System Atrophy. DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated April 2, 2013. Accessed April 19, 2013.
Olivopontocerebellar Atrophy . National Institute of Neurological Disorders and Stroke website. Available at: http://www.ninds.nih.gov/disorders/opca/opca.htm. Accessed April 19, 2013.
Overview of multiple system atrophy. Worldwide Education and Awareness for Movement Disorders website. Available at: http://www.wemove.org/msa/msa.html. Accessed April 19, 2013.
- Reviewer: Rimas Lukas, MD
- Review Date: 03/2014
- Update Date: 05/07/2014