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Principal Proposed Uses
What Is Hibiscus Used for Today?
Adegunloye BJ, Omoniyi JO, Owolabi OA, et al. Mechanisms of the blood pressure lowering effect of the calyx extract of Hibiscus sabdariffa in rats. Afr J Med Med Sci . 1999;25:235–8.
Onyenekwe PC, Ajani EO, Ameh DA, et al. Antihypertensive effect of roselle ( Hibiscus sabdariffa ) calyx infusion in spontaneously hypertensive rats and a comparison of its toxicity with that in Wistar rats. Cell Biochem Funct . 1999;17:199–206.
Haji Faraji M, Haji Tarkhani A. The effect of sour tea ( Hibiscus sabdariffa ) on essential hypertension. J Ethnopharmacol . 1999;65:231–6.
Herrera-Arellano A, Flores-Romero S, Chavez-Soto MA, et al. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial. Phytomedicine . 2004;11:375–82.
Chang YC, Huang HP, Hsu JD, et al. Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells. Toxicol Appl Pharmacol . 2005;205:201–12.
Lin HH, Huang HP, Huang CC, et al. Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway. Mol Carcinog . 2005;43:86–99.
Adetutu A, Odunola OA, Owoade OA, et al. Anticlastogenic effects of Hibiscus sabdariffa fruits against sodium arsenite-induced micronuclei formation in erythrocytes in mouse bone marrow. Phytother Res . 2004;18:862–4.
Tseng TH, Kao TW, Chu CY, et al. Induction of apoptosis by hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma (RB) phosphorylation and Bcl-2 expression. Biochem Pharmacol . 2000;60:307–15.
Chewonarin T, Kinouchi T, Kataoka K, et al. Effects of roselle ( Hibiscus sabdariffa Linn.), a Thai medicinal plant, on the mutagenicity of various known mutagens in Salmonella typhimurium and on formation of aberrant crypt foci induced by the colon carcinogens azoxymethane and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in F344 rats. Food Chem Toxicol . 1999;37:591–601.
Tseng TH, Hsu JD, Lo MH, et al. Inhibitory effect of Hibiscus protocatechuic acid on tumor promotion in mouse skin. Cancer Lett . 1998;126:199–207.
Amin A, Hamza AA. Hepatoprotective effects of Hibiscus , Rosmarinus and Salvia on azathioprine-induced toxicity in rats. Life Sci . 2005;77:266–78.
Wang CJ, Wang JM, Lin WL, et al. Protective effect of Hibiscus anthocyanins against tert-butyl hydroperoxide-induced hepatic toxicity in rats. Food Chem Toxicol . 2000;38:411–6.
Chen CC, Hsu JD, Wang SF, et al. Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. J Agric Food Chem . 2003;51:5472–7.
Chen CC, Chou FP, Ho YC. Inhibitory effects of Hibiscus sabdariffa L extract on low-density lipoprotein oxidation and anti-hyperlipidemia in fructose-fed and cholesterol-fed rats. J Sci Food Agric . 2004;84:1989–96.
Kolawole JA, Maduenyi A. Effect of zobo drink ( Hibiscus sabdariffa water extract) on the pharmacokinetics of acetaminophen in human volunteers. Eur J Drug Metab Pharmacokinet . 2004;29:25–9
Herrera-Arellano A, Miranda-Sanchez J, Avila-Castro P, et al. Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension: a randomized, double-blind, lisinopril-controlled clinical trial. Planta Med . 2007;73:6-12.
Mozaffari-Khosravi H, Jalali-Khanabadi BA, Afkhami-Ardekani M, et al. The effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetes. J Hum Hypertens. 2008 Aug 7.
Wahabi HA, Alansary LA, Al-Sabban AH, et al. The effectiveness of Hibiscus sabdariffa in the treatment of hypertension: a systematic review. Phytomedicine. 2010 Feb;17(2):83.
- Reviewer: EBSCO CAM Review Board
- Review Date: 12/2015
- Update Date: 12/15/2015