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Principal Proposed Uses
- Allergic Rhinitis (Hay Fever)
What is Perilla Used for Today?
Osakabe N, Takano H, Sanbongi C, et al. Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism. Biofactors . 2005;21:127–31.
Takano H, Osakabe N, Sanbongi C, et al. Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans. Exp Biol Med (Maywood) . 2004;229:247–54.
Makino T, Furuta Y, Wakushima H, et al. Anti-allergic effect of Perilla frutescens and its active constituents. Phytother Res . 2003;17:240–3.
Makino T, Furuta A, Fujii H, et al. Effect of oral treatment of Perilla frutescens and its constituents on type-I allergy in mice. Biol Pharm Bull . 2001;24:1206–9.
Renzulli C, Galvano F, Pierdomenico L, et al. Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (Hep G2). J Appl Toxicol . 2004;24:289–96.
Osakabe N, Yasuda A, Natsume M, et al. Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model. Carcinogenesis . 2004;25:549–57.
Youn J, Lee KH, Won J, et al. Beneficial effects of rosmarinic acid on suppression of collagen induced arthritis. J Rheumatol . 2003;30:1203–7.
Makino T, Ono T, Matsuyama K, et al. Suppressive effects of Perilla frutescens on IgA nephropathy in HIGA mice. Nephrol Dial Transplant . 2003;18:484–90.
Takeda H, Tsuji M, Inazu M, et al. Rosmarinic acid and caffeic acid produce antidepressive-like effect in the forced swimming test in mice. Eur J Pharmacol . 2002;449:261–7.
Baolin L, Weiwei W, Ning T. Topical application of luteolin inhibits scratching behavior associated with allergic cutaneous reaction in mice. Planta Med . 2005;71:424–8.
Ueda H, Yamazaki C. Luteolin as an anti-inflammatory and antiallergic constituent of Perilla frutescens . BiolPharm Bull . 2002;25:1197–202.
- Reviewer: EBSCO CAM Review Board
- Review Date: 12/2015
- Update Date: 12/15/2015