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Principal Proposed Uses
- Aging Skin
- Brittle Hair
- Brittle Nails
Institute of Medicine Panel on Micronutrients, Subcommittees on Upper Reference Levels of Nutrients and of Interpretation and Use of Dietary Reference Intakes, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc . Washington, D.C.: National Academies Press; 2000.
Seaborn CD, Nielsen FH. Silicon deprivation decreases collagen formation in wounds and bone, and ornithine transaminase enzyme activity in liver. Biol Trace Elem Res . 2002;89:251–61.
Rico H, Gallego-Lago JL, Hernandez ER, et al. Effect of silicon supplement on osteopenia induced by ovariectomy in rats. Calcif Tissue Int . 2000;66:53–5.
Carlisle EM. Silicon as a trace nutrient. Sci Total Environ . 1989;73:95–106.
Barel A, Calomme M, Timchenko A, et al. Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin. Arch Dermatol Res . 2005 Oct 5 [Epub ahead of print].
Jugdaohsingh R, Anderson SH, Tucker KL, et al. Dietary silicon intake and absorption. Am J Clin Nutr . 2002;75:887–93.
Yin X, Stott MJ. Theoretical insights into bone grafting silicon-stabilized alpha-tricalcium phosphate. J Chem Phys . 2005;122:024709.
Ito M, Abumi K, Moridaira H, et al. Iliac crest reconstruction with a bioactive ceramic spacer. Eur Spine J . 2005;14:99–102.
Wheeler DL, Eschbach EJ, Hoellrich RG, et al. Assessment of resorbable bioactive material for grafting of critical-size cancellous defects. J Orthop Res . 2000;18:140–8.
Radin S, Reilly G, Bhargave G, et al. Osteogenic effects of bioactive glass on bone marrow stromal cells. JBiomed Mater Res A . 2005;73A:21–9.
Phan PV, Grzanna M, Chu J, et al. The effect of silica-containing calcium-phosphate particles on human osteoblasts in vitro. J Biomed Mater Res A . 2003;67:1001–8.
Jugdaohsingh R, Tucker KL, Qiao N, et al. Dietary silicon intake is positively associated with bone mineral density in men and premenopausal women of the Framingham Offspring cohort. J Bone Miner Res . 2004;19:297–307.
Drueke TB, Jouhanneau P, Banide H, et al. Effects of silicon, citrate and the fasting state on the intestinal absorption of aluminium in rats. Clin Sci (Lond) . 1997;92:63–7.
Jugdaohsingh R, Reffitt DM, Oldham C, et al. Oligomeric but not monomeric silica prevents aluminum absorption in humans. Am J Clin Nutr . 2000;71:944–9.
Reffitt DM, Jugdaohsingh R, Thompson RP, et al. Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. J Inorg Biochem . 2000;76:141–7.
Belles M, Albina ML, Sanchez DJ, et al. Lack of protective effects of dietary silicon on aluminium-induced maternal and developmental toxicity in mice. Pharmacol Toxicol . 1999;85:1–6.
Belles M, Sanchez DJ, Gomez M, et al. Silicon reduces aluminum accumulation in rats: relevance to the aluminum hypothesis of Alzheimer disease. Alzheimer Dis Assoc Disord . 1998;12:83–7.
U.K. Food Standards Agency. Risk assessment – silicon. Available at: http://www.food.gov.uk/multimedia/pdfs/evm%5Fsilicon.pdf . Accessed July 7, 2005.
Spector T, Calomme M, Anderson S, et al. Effect on bone turnover and BMD of low dose oral silicon as an adjunct to calcium/vitamin D3 in a randomized, placebo-controlled trial. Poster presentation, ASBMR 27th Annual Meeting, Nashville, Tennessee, September 2005.
Wickett RR, Kossmann E, Barel A, et al. Effect of oral intake of choline-stabilized orthosilicic acid on hair tensile strength and morphology in women with fine hair. Arch Dermatol Res. 2007 Oct 25. [Epub ahead of print]
- Reviewer: EBSCO CAM Review Board
- Review Date: 12/2015
- Update Date: 12/15/2015