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Principal Proposed Uses
- Fix or reverse genetic defects that allow cancer cells to take hold, grow, spread, or return after treatment27,30
- Kill cancer cells when combined with chemotherapy for cancer treatment28,30
- Create a protective environment against the development of neurological diseases, such as stroke, traumatic brain injury, and Parkinson and Alzheimer disease29,30
- Ease chronic inflammation and reduce its effects on the body30
Interactions You Should Know About
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Fahey JW, Haristoy X, Dolan PM, et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci USA . 2002;99:7610–7615.
Hecht SS. Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism. J Nutr . 1999;129:768S–74S.
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Nestle M. Broccoli sprouts as inducers of carcinogen-detoxifying enzyme systems: clinical, dietary, and policy implications. Proc Natl Acad Sci. 1997;94:11149–51.
Fahey JW, Talalay P. Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes. Food Chem Toxicol . 1999;37:973–979.
Gamet-Payrastre L, Li P, Lumeau S, et al. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res . 2000;60:1426–1433.
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Frydoonfar HR, McGrath DR, Spigelman AD. The effect of indole-3-carbinol and sulforaphane on a prostate cancer cell line. ANZ J Surg . 2003;73:154–6.
Chiao JW, Chung FL, Kancherla R, Ahmed T, Mittelman A, Conaway CC. Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells. Int J Oncol . 2002;20:631–6.
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Brooks JD, Paton VG, Vidanes G. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Cancer Epidemiol Biomarkers Prev . 2001;10:949–54.
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Kelloff GJ, Crowell JA, Steele VE, et al. Progress in cancer chemoprevention: development of diet-derived chemopreventive agents. J Nutr . 2000;130(2S Suppl):467S–471S.
Kunz R, Oxman AD. The unpredictability paradox: review of empirical comparisons of randomised and non-randomised clinical trials. BMJ . 1998;317:1185–90.
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Tortorella SM, Royce SG, Licciardi PV, Karagiannis TC. Dietary sulforaphane in cancer chemoprevention: the role of epigenetic regulation and HDAC inhibition. Antioxid Redox Signal. 2015;22(16):1382-1424.
Lee YJ, Lee SH. Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells. Mol Med Rep. 2017 June 15 [Epub ahead of print].
Tarozzi A, Angeloni C, Malaguti M, Morroni F, Hrelia S, Hrelia P. Sulforaphane as a potential protective phytochemical against neurodegenerative diseases. Oxid Med Cell Longev. 2013 Jul 25 [Epub head of print].
Kim JK, Park SU. Current potential health benefits of sulforaphane. EXCLI J. 2016;15:571-577.
- Reviewer: EBSCO CAM Review Board
- Review Date: 12/2015
- Update Date: 07/05/2017